Chicken globin genes. Nucleotide sequence of cDNA clones coding for the alpha-globin expressed during hemolytic anemia.
نویسندگان
چکیده
منابع مشابه
Chicken /3-Globin Genes
We reported previously that DNA bend sites appear in the human /3-globin locus at an average distance of 680 bp. The relative locations of the sites were conserved among the five active /3-like globin genes and one pseudogene. Here, we mapped the sites in the /3-like globin genes from various species and examined their conservation. The locations of the bend sites in the bovine, rabbit and chic...
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_________________________________________________________________________________________________ *Correspondence: Razin, Sergey, Ph.D, Institute of Gene Biology RAS, Vavilov Str. 34/5, 117334 Moscow, Russia e-mail: [email protected], [email protected],[email protected]
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Using complementary DNA prepared from adult chicken globin messenger RNA, we show the existence of 2-3 non-cross-hybridising globin sequences in the chicken genome, each of which is present in only one copy per haploid genome. This was done by solution hybridization to total DNA under conditions of cDNA excess. The data agreses with results of RNA-driven hybridisation of globin complementary DN...
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The α-globin genes were studied in nine families with unexplained hypochromic anaemia and in 167 patients with HbE β thalassaemia in Sri Lanka. As well as the common deletion forms of α(+) thalassaemia three families from an ethnic minority were found to carry a novel form of α(0) thalassaemia, one family carried a previously reported form of α(0) thalassaemia, --(THAI), and five families had d...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1980
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)70562-6